Search results for "Iodoacetic Acid"
showing 3 items of 3 documents
Agkistrodon ameliorates pain response and prevents cartilage degradation in monosodium iodoacetate-induced osteoarthritic rats by inhibiting chondroc…
2019
Abstract Ethnopharmacological relevance Osteoarthritis (OA), characterized by joint pain and cartilage degradation, is the most common form of joint disease worldwide but with no satisfactory therapy available. The ethanol extract of Agkistrodon acutus (EAA) has been widely used as a traditional Chinese medicine (TCM) for the treatment of arthralgia and inflammatory diseases, but there is no report regarding its efficacy on OA to date. Here, we determined the effects of EAA on the pain behavior and cartilage degradation in vivo and clarified its target genes and proteins associated with chondrocyte hypertrophy and apoptosis in vitro. Materials and methods In vivo OA model was established by…
l-[3H]lysine binding to rat retinal membrane: II. effect of kainic acid,d,l-?-aminoadipic acid, iodoacetic acid, and modification by dark-exposure
1986
The rat retina and the different brain regions contain membranes sites that bindl-lysine in the nanomolar range. These binding sites undergo changes in different experimental conditions, thus: I) intraocular injection of kainic acid induces a reduction of the density ofl-lysine binding sites, II)d,l-α-aminoadipic acid injected into the eye enhances both kinetic parameters (Bmax andKd) ofl-[3H]lysine binding sites, III) the intraperitoneal injection of iodoacetic acid decreases the sensitivity for its ligand binding sites, and IV) the exposure to darkness of the rats reducesl-[3H]lysine binding in the retina, thalamus, hypothalamus and superior colliculus, but not in the occipital cortex; su…
Der Einflu� von Monojodessigs�ure auf das Aktionspotential des Rattenzwerchfells
1959
1. The action of iodoacetic acid (IA) was studied on the isolated rat diaphragm at 20–22° C. Membrane and action potentials were led off with intracellular microelectrodes. 2. IA causes a contracture which is complete in 4 hours. As long as t he contracture develops, the membrane potential remains constant. A contracture identical with that seen in a normal preparation can be produced by IA in the presence of isotonic K2SO4. 3. The amplitude of the action potential is only slightly reduced during the first two hours after addition of IA. The duration of the action potential is significantly increased. Finally, action potentials with a plateau are obtained which resemble those of normal vent…